Why does a cold pool feel warmer the second time you dip your toes in? Why does a safecracker run his fingers over sandpaper? Why do Mediterranean cultures touch each other more than Scandinavian cultures? Would it be great — or not so great — if you were unable to feel physical pain? Why does stubbing your toe have different sensations through time? And what does any of this have to do with cuddle puddles, NBA players bumping chests, or puppies sleeping in dog piles? Today’s episode is a love story about our sense of touch: what it is, how it works, and why it plays such a critical role in our lives.

Episode Audio

Episode Video

More Information:

Eagleman D, Downar J. (2016). Brain and behavior: a cognitive neuroscience perspective. Oxford University Press. 2016.

Linden DJ (2015). Touch. Viking Books.

Braz J, Solorzano C, Wang X, Basbaum AI. (2014). Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control. Neuron. 2014 May 7;82(3):522-36.

Cole J, Paillard J. (1995). Living without touch and peripheral information about body position and movement: Studies with deafferented subjects. The body and the self (pp. 245–266). The MIT Press.

Craig AD. (2002). How do you feel? Interoception: the sense of the physiological condition of the body. Nature reviews neuroscience. 2002 Aug 1;3(8):655-66.

Frias B, Merighi A. (2016). Capsaicin, nociception and pain. Molecules. 2016 Jun 18;21(6):797.

Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001 Sep 13;413(6852):203-10.

Minett MS, Pereira V, Sikandar S, Matsuyama A, Lolignier S, Kanellopoulos AH, Mancini F, Iannetti GD, Bogdanov YD, Santana-Varela S, Millet Q. (2015). Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1. 7. Nature communications. 2015 Dec 4;6(1):8967.

Prescott SA, Ma Q, De Koninck Y. (2014). Normal and abnormal coding of somatosensory stimuli causing pain. Nature neuroscience. 2014 Feb;17(2):183-91.

Ranade SS, Syeda R, Patapoutian A. (2015). Mechanically activated ion channels. Neuron. 2015 Sep 23;87(6):1162-79.

Schepers RJ, Ringkamp M. (2010). Thermoreceptors and thermosensitive afferents. Neuroscience & Biobehavioral Reviews. 2010 Feb 1;34(2):177-84.

Viana F, de la Peña E, Belmonte C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nature neuroscience. 2002 Mar 1;5(3):254-60.

Woods CG, Babiker MO, Horrocks I, Tolmie J, Kurth I. (2015). The phenotype of congenital insensitivity to pain due to the NaV1. 9 variant p. L811P. European Journal of Human Genetics. 2015 May;23(5):561-3.

Zaki J, Wager TD, Singer T, Keysers C, Gazzola V. (2016). The anatomy of suffering: understanding the relationship between nociceptive and empathic pain. Trends in cognitive sciences. 2016 Apr 1;20(4):249-59.

SUBSCRIBE AND LISTEN ON:

"David Eagleman is the kind of guy who really does make being a neuroscientist look like fun."
- New York Times
"David Eagleman may be the best combination of scientist and fiction-writer alive."
- Stewart Brand
"What Eagleman seems to be calling for is a new Enlightenment."
- Sunday Herald
"[A] neuroscientist and polymath."
- Wall Street Journal
"David Eagleman offers startling lessons.... His method is to ask us to cast off our lazy commonplace assumptions.
- The Guardian
"Eagleman has a talent for testing the untestable, for taking seemingly sophomoric notions and using them to nail down the slippery stuff of consciousness."
- The New Yorker
"A popularizer of impressive gusto...[Eagleman] aims, grandly, to do for the study of the mind what Copernicus did for the study of the stars."
- New York Observer